Abstract
Cytogenetic investigation of a nodal diffuse large B cell lymphoma carrying an IGH-BCL2-fusion revealed a homogeneously staining region at chromosome 1p21-22. Fluorescence in situ hybridisation (FISH) demonstrated heterogeneous BCL10 gene amplification in tumour cells. Immunohistochemistry showed heterogeneous over-expression of the protein in the nuclei of tumour cells, similar to that seen in MALT lymphoma cells with t(1;14)(p22;q32).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing / genetics*
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B-Cell CLL-Lymphoma 10 Protein
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Caspases / genetics
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Chromosome Mapping
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Chromosomes, Human, Pair 1
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Chromosomes, Human, Pair 14
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Forkhead Transcription Factors / genetics
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Gene Amplification
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Gene Expression Regulation, Neoplastic
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Humans
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Immunoglobulin Heavy Chains / genetics*
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Lymphoma, B-Cell / genetics*
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Lymphoma, B-Cell / pathology
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Lymphoma, Large B-Cell, Diffuse / genetics*
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Lymphoma, Large B-Cell, Diffuse / pathology
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Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
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Neoplasm Proteins / genetics
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Recombinant Fusion Proteins / genetics
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Repressor Proteins / genetics
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Translocation, Genetic
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bcl-2-Associated X Protein / genetics*
Substances
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Adaptor Proteins, Signal Transducing
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B-Cell CLL-Lymphoma 10 Protein
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BCL10 protein, human
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FOXP1 protein, human
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Forkhead Transcription Factors
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Immunoglobulin Heavy Chains
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Neoplasm Proteins
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Recombinant Fusion Proteins
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Repressor Proteins
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bcl-2-Associated X Protein
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Caspases
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MALT1 protein, human
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Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein