Abstract
The SOX group E transcription factors play an integral role in the specification and differentiation of astrocytes and oligodendrocytes. We have examined the pattern of expression for SOX9 and SOX10 in primary brain tumors by immunohistochemistry. Pediatric and adult high grade tumors display strong nuclear staining for both SOX9 and SOX10 (astrocytic, oligodendroglial and primitive neuroectodermal tumors). In comparison pediatric pilocytic astrocytoma express much less SOX9 and SOX10. Reactive astrogliosis is characterized by an increase of SOX9 only.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Astrocytes / metabolism
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Cell Nucleus / pathology
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Central Nervous System Neoplasms / metabolism*
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Central Nervous System Neoplasms / pathology
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Child
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Child, Preschool
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DNA-Binding Proteins / biosynthesis*
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DNA-Binding Proteins / genetics*
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Gene Expression Regulation, Neoplastic / genetics
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Gliosis / pathology
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High Mobility Group Proteins / biosynthesis*
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High Mobility Group Proteins / genetics*
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Humans
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Immunohistochemistry
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Neoplasms, Neuroepithelial / metabolism*
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Neoplasms, Neuroepithelial / pathology
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Oligodendroglia / metabolism
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Paraffin Embedding
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SOX9 Transcription Factor
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SOXE Transcription Factors
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Transcription Factors / biosynthesis*
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Transcription Factors / genetics*
Substances
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DNA-Binding Proteins
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High Mobility Group Proteins
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SOX10 protein, human
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SOX9 Transcription Factor
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SOX9 protein, human
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SOXE Transcription Factors
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Transcription Factors