Abstract
HLA system plays a key role in the tumor cells' escape from immune surveillance. Herein is the first report on the correlation of the susceptibility to breast cancer with HLA class II markers in Tunisia. Molecular typing of HLA-DRB1 and -DQB1 loci was undertaken for 70 Tunisian female patients. Comparison of allele and haplotype distribution between patients and 70 female control subjects reveals a negative association between HLADRB1* 07-DQB1*02 and the incidence of breast cancer in the Tunisian population.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Alleles
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Breast Neoplasms / epidemiology*
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Breast Neoplasms / genetics*
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Breast Neoplasms / prevention & control
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Case-Control Studies
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Female
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Genes, MHC Class II / genetics*
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Genetic Predisposition to Disease*
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HLA-DQ Antigens / genetics
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HLA-DQ beta-Chains
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HLA-DR Antigens / genetics
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HLA-DRB1 Chains
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Haplotypes / genetics
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Histocompatibility Antigens Class II / genetics
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Humans
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Incidence
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Linkage Disequilibrium / genetics
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Middle Aged
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Polymorphism, Genetic
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Risk Factors
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Tunisia / epidemiology
Substances
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HLA-DQ Antigens
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HLA-DQ beta-Chains
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HLA-DQB1 antigen
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HLA-DR Antigens
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HLA-DRB1 Chains
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Histocompatibility Antigens Class II