Abstract
B lymphocyte-induced maturation protein (Blimp)-1, a transcriptional repressor, has long been known to drive the terminal maturation of B cells into plasma cells. However, two recent studies reveal an unanticipated role for Blimp-1 in T-cell homeostasis. Blimp-1-deficient T cells exhibit enhanced proliferative and functional responses following activation, and induce spontaneous colitis. Hence, aside from its role in B-cell differentiation, Blimp-1 directs restraint among T cells.
MeSH terms
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Animals
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B-Lymphocytes / immunology
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Cell Differentiation
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Cell Proliferation
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Colitis / metabolism
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Homeostasis
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Humans
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Models, Biological
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Positive Regulatory Domain I-Binding Factor 1
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Repressor Proteins / genetics
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Repressor Proteins / immunology
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Repressor Proteins / physiology*
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T-Lymphocytes / physiology*
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Transcription Factors / genetics
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Transcription Factors / immunology
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Transcription Factors / physiology*
Substances
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Repressor Proteins
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Transcription Factors
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PRDM1 protein, human
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Positive Regulatory Domain I-Binding Factor 1