Abstract
The multidrug resistance phenotype is associated with expression of P-glycoprotein (P-gp), an energy-dependent drug efflux pump. P-gp is expressed in several clinically resistant human cancers. This article discusses the evidence that P-gp expression may be implicated in the development of clinical drug resistance in patients with breast cancer.
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Antineoplastic Agents / therapeutic use*
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Breast Neoplasms / drug therapy*
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Breast Neoplasms / genetics
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Drug Resistance / genetics
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Female
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Humans
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Membrane Glycoproteins* / isolation & purification
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Neoplasm Proteins* / isolation & purification
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Phenotype
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Antineoplastic Agents
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Membrane Glycoproteins
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Neoplasm Proteins