Abstract
Preliminary investigations, studying gene expression and biochemical activities of enzymes d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 (KAT-1), revealed elevated cerebellar KAT-1 and DAAO activities in post-mortem brain samples from schizophrenic versus normal individuals. In addition, we have identified a transcript of DAAO, which was expressed in significantly higher quantities in the diseased cerebellum but not detected in the parietal cortex where DAAO activity is absent.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alternative Splicing / genetics
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Animals
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Cerebellum / enzymology*
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Cerebellum / physiopathology
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D-Amino-Acid Oxidase / genetics
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D-Amino-Acid Oxidase / metabolism*
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Gene Expression Regulation, Enzymologic / physiology
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Humans
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Ligands
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Models, Neurological
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Parietal Lobe / enzymology
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Parietal Lobe / physiopathology
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Protein Isoforms / genetics
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Protein Isoforms / metabolism
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RNA, Messenger / analysis
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RNA, Messenger / metabolism
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Rats
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Rats, Inbred WKY
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Receptors, Glycine / metabolism*
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Receptors, N-Methyl-D-Aspartate / metabolism*
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Schizophrenia / enzymology*
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Schizophrenia / physiopathology
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Synaptic Transmission / physiology
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Transaminases / genetics
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Transaminases / metabolism*
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Up-Regulation / physiology
Substances
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Ligands
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Protein Isoforms
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RNA, Messenger
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Receptors, Glycine
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Receptors, N-Methyl-D-Aspartate
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D-Amino-Acid Oxidase
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Transaminases
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kynurenine-oxoglutarate transaminase