Hepatocyte growth factor: new arsenal in the fights against renal fibrosis?

Y Liu; J Yang

doi:10.1038/sj.ki.5001661

Hepatocyte growth factor: new arsenal in the fights against renal fibrosis?

Kidney Int. 2006 Jul;70(2):238-40. doi: 10.1038/sj.ki.5001661.

Authors

Y Liu¹, J Yang

Affiliation

¹ Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA. liuy@upmc.edu

PMID: 16838037
DOI: 10.1038/sj.ki.5001661

Abstract

Hepatocyte growth factor (HGF) has emerged as a potent, endogenous antifibrotic factor that shows an impressive efficacy in ameliorating tissue fibrosis in a wide variety of animal models. Herrero-Fresneda et al. provide new evidence demonstrating that intramuscular injection of HGF gene reduces mortality, inflammation, and renal fibrosis in chronic allograft nephropathy.

Publication types

Comment
Review

MeSH terms

Animals
Fibrosis
Genetic Therapy / methods*
Hepatocyte Growth Factor / genetics*
Humans
Kidney / immunology
Kidney / pathology
Kidney Failure, Chronic / pathology
Kidney Failure, Chronic / surgery
Kidney Failure, Chronic / therapy*
Kidney Transplantation
Nephritis / immunology
Nephritis / pathology
Nephritis / therapy
Postoperative Complications / immunology
Postoperative Complications / pathology
Postoperative Complications / therapy

Substances

Hepatocyte Growth Factor