Abstract
Cytochrome P450 (CYP) enzyme 2J2, an epoxygenase predominantly expressed in the heart, metabolizes arachidonic acid to biologically active eicosanoids. One of the CYP2J2 products, 11,12-epoxyeicosatrienoic acid, has several vasoprotective effects. A frequent promoter polymorphism of CYP2J2 decreases gene expression and is associated with coronary artery disease. This association supports the vascular protective role of CYP-derived eicosanoids in cardiovascular disease.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Coronary Artery Disease / enzymology*
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Coronary Artery Disease / genetics
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Cytochrome P-450 CYP2J2
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Cytochrome P-450 Enzyme System / biosynthesis*
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Cytochrome P-450 Enzyme System / genetics
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Eicosanoids / biosynthesis
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Endothelium, Vascular / metabolism
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Gene Expression Regulation
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Humans
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Oxygenases / biosynthesis*
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Oxygenases / genetics
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Polymorphism, Genetic
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Promoter Regions, Genetic / genetics
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Risk Factors
Substances
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CYP2J2 protein, human
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Eicosanoids
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Cytochrome P-450 Enzyme System
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Oxygenases
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Cytochrome P-450 CYP2J2