Abstract
E-selectin, which is a member of the selectin superfamily of adhesion molecules, contributes to the leukocyte-endothelial cell attachments and is involved in the pathogenesis of thrombovascular diseases as a consequence. We investigated the A561C mutation in the E-selectin gene in 235 Japanese patients with ischemic cerebrovascular disease (CVD) and 301 age- and sex-matched healthy controls. Excluding the subjects with diabetes mellitus and hypercholesterolemia, the AC genotype frequencies of patients with ischemic CVD were higher than those of controls: 12.7% vs. 5.8% (P=0.04). Our results show that E-selectin gene polymorphisms represent an increased risk for ischemic CVD in the Japanese population without diabetes mellitus and hypercholesterolemia.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Brain Ischemia / ethnology
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Brain Ischemia / genetics*
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Brain Ischemia / metabolism
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Cell Adhesion / genetics
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Cerebral Arteries / metabolism*
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Cerebral Arteries / physiopathology
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Cerebrovascular Disorders / ethnology
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Cerebrovascular Disorders / genetics*
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Cerebrovascular Disorders / metabolism
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Chemotaxis, Leukocyte / genetics
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Diabetes Complications / ethnology
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Diabetes Complications / genetics
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Diabetes Complications / metabolism
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E-Selectin / genetics*
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Female
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Genetic Predisposition to Disease / genetics*
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Humans
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Hypercholesterolemia / ethnology
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Hypercholesterolemia / genetics
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Hypercholesterolemia / metabolism
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Intracranial Thrombosis / ethnology
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Intracranial Thrombosis / genetics
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Intracranial Thrombosis / metabolism
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Japan / ethnology
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Male
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Middle Aged
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Polymorphism, Genetic / genetics*
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Risk Factors