Alteration of the influences of HLA classes I and II alleles on the perinatal hepatitis B virus infection after immunoprophylaxis in Korean children

Jong-Hyun Kim; Chul-Woo Pyo; Dae Kyun Koh; Jae Kyun Hur; Jin Han Kang; Tai-Gyu Kim

doi:10.1016/j.hepres.2006.03.004

Alteration of the influences of HLA classes I and II alleles on the perinatal hepatitis B virus infection after immunoprophylaxis in Korean children

Hepatol Res. 2006 Jun;35(2):118-26. doi: 10.1016/j.hepres.2006.03.004.

Authors

Jong-Hyun Kim¹, Chul-Woo Pyo, Dae Kyun Koh, Jae Kyun Hur, Jin Han Kang, Tai-Gyu Kim

Affiliation

¹ Department of Pediatrics, St. Vincent's Hospital, The Catholic University of Korea, 93 Ji-dong, Paldal-gu, Suwon, Kyonggi-do 442-060, Republic of Korea.

PMID: 16890179
DOI: 10.1016/j.hepres.2006.03.004

Abstract

Some HLA alleles are known to be associated with hepatitis B virus (HBV) persistence. In order to find out the relationship between HLA and perinatal HBV infection after prophylaxis, we typed HLA classes I and II in 38 HBeAg-positive mothers, their children (19 succeeded and 19 failed in prophylaxis) and 198 HBsAg-negative healthy controls. HLA-B35 (RR=2.8, p<0.03), Cw*07 (RR=2.7, p<0.02), DRB1*07 (RR=3.6, p<0.006), DQA1*02 (RR=3.6, p<0.02) and DQB1*02 (RR=2.4, p<0.05) alleles were higher and DRB1*13 (RR=0.3, p<0.03) and DPB1*0401 (RR=0.1, p<0.01) alleles were lower frequencies in HBeAg-positive mothers than in the control. In failed children to the perinatal HBV prophylaxis, HLA-Cw*0303 allele was significantly higher (p<0.05) and DPB1*0202 allele was lower (p<0.03) than in succeeded children. These results suggest the influences of certain HLA alleles on naturally acquired chronic HBV infection may be changed by perinatal HBV prophylaxis.