ErbB2 makes beta 4 integrin an accomplice in tumorigenesis

Cell. 2006 Aug 11;126(3):443-5. doi: 10.1016/j.cell.2006.07.020.

Abstract

Integrins modulate signaling by growth factor receptors, but their role during tumorigenesis is not clear. Guo et al. (2006) now demonstrate that alpha 6 beta 4 integrin cooperates with ErbB2 in the formation of mammary tumors and discover distinct pathways that regulate cellular proliferation and adhesion downstream of the ErbB2-integrin complex.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Carcinoma / metabolism*
  • Carcinoma / physiopathology
  • Cell Adhesion / physiology
  • Cell Polarity / physiology
  • Cell Proliferation
  • Cell Transformation, Neoplastic / genetics
  • Cell Transformation, Neoplastic / metabolism*
  • Epithelial Cells / metabolism
  • Epithelial Cells / pathology
  • Humans
  • Integrin alpha6beta4 / metabolism*
  • Receptor, ErbB-2 / metabolism*
  • Signal Transduction / physiology
  • Tight Junctions / metabolism

Substances

  • Integrin alpha6beta4
  • Receptor, ErbB-2