Abstract
We studied 100 well-characterized E. coli blood isolates from patients with urosepsis for their susceptibility to nalidixic acid, ampicillin and trimethoprim-sulfamethoxazole, according to prevalence of virulence factors, phylogenetic groups and subgroups, PAI II(J96)-like domains (determined by physical linkage of cnf1, hly and hra) and PAI I(CFT073)-like domains (determined by physical linkage of papGII to the hly locus). Nalidixic acid resistance was associated with a lower prevalence of sfa/foc, K1 antigen, pathogenicity island II(J96)-like domains, subgroup B2/I and a shift towards group A.
MeSH terms
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Ampicillin / pharmacology
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Anti-Infective Agents / pharmacology
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Drug Resistance, Bacterial / genetics*
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Escherichia coli / drug effects*
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Escherichia coli / genetics
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Escherichia coli / isolation & purification
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Escherichia coli Infections / microbiology
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Genomic Islands / genetics*
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Humans
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Microbial Sensitivity Tests
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Nalidixic Acid / pharmacology
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Phylogeny*
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Polymerase Chain Reaction
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Sepsis / microbiology*
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Trimethoprim, Sulfamethoxazole Drug Combination / pharmacology
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Urinary Tract Infections / microbiology*
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Virulence Factors / genetics*
Substances
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Anti-Infective Agents
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Virulence Factors
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Nalidixic Acid
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Ampicillin
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Trimethoprim, Sulfamethoxazole Drug Combination