Phylogenetic background and carriage of pathogenicity island-like domains in relation to antibiotic resistance profiles among Escherichia coli urosepsis isolates

J Antimicrob Chemother. 2006 Oct;58(4):748-51. doi: 10.1093/jac/dkl326. Epub 2006 Aug 10.

Abstract

We studied 100 well-characterized E. coli blood isolates from patients with urosepsis for their susceptibility to nalidixic acid, ampicillin and trimethoprim-sulfamethoxazole, according to prevalence of virulence factors, phylogenetic groups and subgroups, PAI II(J96)-like domains (determined by physical linkage of cnf1, hly and hra) and PAI I(CFT073)-like domains (determined by physical linkage of papGII to the hly locus). Nalidixic acid resistance was associated with a lower prevalence of sfa/foc, K1 antigen, pathogenicity island II(J96)-like domains, subgroup B2/I and a shift towards group A.

MeSH terms

  • Ampicillin / pharmacology
  • Anti-Infective Agents / pharmacology
  • Drug Resistance, Bacterial / genetics*
  • Escherichia coli / drug effects*
  • Escherichia coli / genetics
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / microbiology
  • Genomic Islands / genetics*
  • Humans
  • Microbial Sensitivity Tests
  • Nalidixic Acid / pharmacology
  • Phylogeny*
  • Polymerase Chain Reaction
  • Sepsis / microbiology*
  • Trimethoprim, Sulfamethoxazole Drug Combination / pharmacology
  • Urinary Tract Infections / microbiology*
  • Virulence Factors / genetics*

Substances

  • Anti-Infective Agents
  • Virulence Factors
  • Nalidixic Acid
  • Ampicillin
  • Trimethoprim, Sulfamethoxazole Drug Combination