Activation of the MMP-1 promoter by cigarette smoke in human small airway epithelial cells requires ERK MAP kinase signaling: differential response of the 1G and 2G promoter sequences

Proc Am Thorac Soc. 2006 Aug;3(6):477. doi: 10.1513/pats.200603-041MS.

Authors

Becky Mercer¹, Constance Brinckerhoff, Jeanine D'Armiento

Affiliation

¹ Department of Medicine, Division of Molecular Medicine, Institute of Human Nutrition, Columbia University, College of Physicians & Surgeons, New York, NY 10032, USA.

PMID: 16921115
DOI: 10.1513/pats.200603-041MS

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

DNA / genetics*
Enzyme Activation / genetics
Extracellular Signal-Regulated MAP Kinases / metabolism*
Gene Expression
Genetic Predisposition to Disease
Humans
Matrix Metalloproteinase 1 / genetics*
Matrix Metalloproteinase 1 / metabolism
Polymorphism, Genetic*
Promoter Regions, Genetic / genetics
Pulmonary Disease, Chronic Obstructive / enzymology
Pulmonary Disease, Chronic Obstructive / genetics
Respiratory Mucosa / enzymology*
Respiratory Mucosa / pathology
Signal Transduction / genetics*
Smoking / genetics*
Smoking / metabolism
Smoking / pathology

Substances

DNA
Extracellular Signal-Regulated MAP Kinases
Matrix Metalloproteinase 1