Intralesional therapy of metastatic spreading melanoma with beta-interferon

J Dtsch Dermatol Ges. 2006 Sep;4(9):743-6. doi: 10.1111/j.1610-0387.2006.06054.x.
[Article in English, German]

Abstract

A 74-year-old female patient developed multiple local metastases after excision of a nodular melanoma of the left cheek. There was no regression after treatment with dacarbazine (DTIC) and radiotherapy. After treatment with intralesional interferon-beta, the metastases regressed completely. The dosage was 5 million IU interferon-beta (Fiblaferon) three times weekly with courses of two and four weeks, separated by a month. Except for local swelling and inflammation, no side effects occurred. Five years after completing therapy, the patient is still tumor-free.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Agents / administration & dosage
  • Facial Neoplasms / drug therapy*
  • Facial Neoplasms / secondary*
  • Female
  • Humans
  • Injections, Intralesional
  • Interferon-beta / administration & dosage*
  • Melanoma / drug therapy*
  • Melanoma / secondary*
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / secondary*
  • Treatment Outcome

Substances

  • Antineoplastic Agents
  • Interferon-beta