Abstract
BAFF is a key factor controlling B cell survival and maturation and its over-expression promotes B cell-mediated autoimmune disorders and participates in the progression of B cell lymphomas. Yet, BAFF and a related ligand APRIL are expressed by T lymphocytes and modulate their functions. BAFF and APRIL promote T cell activation and survival. BAFF over-expression in transgenic (Tg) mice enhances T helper 1 (Thl)-driven delayed-type hypersensitivity (DTH), but inhibits T helper 2 (Th2) cell-mediated allergic airway inflammation in mice. Some of these effects are also dependent on BAFF-induced modification of the B cell compartment. Therefore, direct BAFF/APRIL signalling in T cells and/or T cell modulation in response to a BAFF-modified B cell compartment may play an important role in inflammation and immunomodulation.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Autoimmunity / immunology
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B-Cell Activating Factor / deficiency
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B-Cell Activating Factor / genetics
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B-Cell Activating Factor / immunology*
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B-Cell Activation Factor Receptor / deficiency
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B-Cell Activation Factor Receptor / genetics
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B-Cell Activation Factor Receptor / immunology*
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B-Cell Maturation Antigen / deficiency
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B-Cell Maturation Antigen / genetics
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B-Cell Maturation Antigen / immunology*
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Cell Differentiation
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Homeodomain Proteins / genetics
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Homeodomain Proteins / physiology
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Humans
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Inflammation / immunology
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Lymphocyte Activation
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Lymphokines / biosynthesis
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Mice
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Mice, Knockout
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Mice, Transgenic
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T-Lymphocyte Subsets / immunology*
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T-Lymphocyte Subsets / metabolism
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Transmembrane Activator and CAML Interactor Protein / deficiency
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Transmembrane Activator and CAML Interactor Protein / genetics
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Transmembrane Activator and CAML Interactor Protein / immunology*
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Tumor Necrosis Factor Ligand Superfamily Member 13 / genetics
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Tumor Necrosis Factor Ligand Superfamily Member 13 / immunology*
Substances
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B-Cell Activating Factor
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B-Cell Activation Factor Receptor
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B-Cell Maturation Antigen
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Homeodomain Proteins
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Lymphokines
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TNFRSF13B protein, human
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TNFRSF13C protein, human
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TNFSF13 protein, human
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TNFSF13B protein, human
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Tnfrsf13b protein, mouse
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Tnfrsf13c protein, mouse
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Tnfsf13 protein, mouse
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Tnfsf13b protein, mouse
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Transmembrane Activator and CAML Interactor Protein
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Tumor Necrosis Factor Ligand Superfamily Member 13
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RAG-1 protein