Abstract
Recent evidence suggests that neuropeptide Y (NPY) may be involved in the neurobiological responses to drugs of abuse. This study was designed to assess the possible contribution of NPY to opiate withdrawal behaviors. Here we report that mice lacking the NPY gene show normal conditioned place aversion to opiate withdrawal, but show attenuated opiate withdrawal somatic signs.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Avoidance Learning / drug effects
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Avoidance Learning / physiology
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Behavior, Animal / drug effects
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Behavior, Animal / physiology
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Brain / drug effects*
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Brain / metabolism*
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Brain / physiopathology
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Brain Chemistry / genetics
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Conditioning, Psychological / drug effects
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Conditioning, Psychological / physiology
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Down-Regulation / genetics*
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Fear / drug effects
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Fear / physiology
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Limbic System / drug effects
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Limbic System / metabolism
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Limbic System / physiopathology
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Male
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Mice
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Mice, Knockout
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Morphine / adverse effects
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Motor Activity / drug effects
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Motor Activity / genetics
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Narcotic Antagonists / pharmacology
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Narcotics / adverse effects
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Neural Pathways / drug effects
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Neural Pathways / metabolism
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Neural Pathways / physiopathology
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Neuropeptide Y / genetics*
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Opioid-Related Disorders / genetics
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Opioid-Related Disorders / metabolism*
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Opioid-Related Disorders / physiopathology
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Substance Withdrawal Syndrome / genetics
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Substance Withdrawal Syndrome / metabolism*
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Substance Withdrawal Syndrome / physiopathology
Substances
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Narcotic Antagonists
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Narcotics
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Neuropeptide Y
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Morphine