Abstract
MLL/GAS7, resulting from t(11;17)(q23;p13), has been reported in one case of treatment-related acute myeloid leukemia (AML). We present a de novo case of t(11;17)-positive pediatric acute lymphoblastic leukemia. Fluorescent in situ hybridization and reverse transcriptase polymerase chain reaction analyses revealed an MLL/GAS7 chimera identical to the one previously described in AML. The molecular genetic features of MLL/GAS7 and the clinical impact of t(11;17) are discussed.
Publication types
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Case Reports
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Chromosomes, Human, Pair 11
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Chromosomes, Human, Pair 17
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Female
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Humans
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Infant
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Myeloid-Lymphoid Leukemia Protein / genetics
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Nerve Tissue Proteins / genetics
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Oncogene Proteins, Fusion / genetics*
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Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
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Translocation, Genetic*
Substances
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GAS7 protein, human
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MLL-GAS7 fusion protein
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Nerve Tissue Proteins
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Oncogene Proteins, Fusion
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Myeloid-Lymphoid Leukemia Protein