Lack of involvement of the G-CSF gene by chromosomal translocation t(15;17) in acute promyelocytic leukemia

S Tanaka; H Nishigaki; S Misawa; M Taniwaki; H Nakagawa; H Yashige; S Horiike; K Kashima; J Inazawa; Y Sonoda

Lack of involvement of the G-CSF gene by chromosomal translocation t(15;17) in acute promyelocytic leukemia

Leukemia. 1990 Jul;4(7):494-6.

Authors

S Tanaka¹, H Nishigaki, S Misawa, M Taniwaki, H Nakagawa, H Yashige, S Horiike, K Kashima, J Inazawa, Y Sonoda, et al.

Affiliation

¹ Third Department of Medicine, Kyoto Prefectural University of Medicine, Japan.

PMID: 1695704

Abstract

Using a human G-CSF cDNA as a probe, we analyzed the t(15;17) breakpoint by Southern blot analysis with conventional and/or pulsed-field gel electrophoresis in 12 patients with acute promyelocytic leukemia. The results did not show the rearrangement, deletion, or restriction fragment length polymorphism within the gene and in the surrounding sequences.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Blotting, Southern
Chromosome Mapping
Chromosomes, Human, Pair 15 / physiology
Chromosomes, Human, Pair 17 / physiology
Colony-Stimulating Factors / genetics*
DNA Restriction Enzymes / metabolism
Electrophoresis, Agar Gel / methods
Female
Granulocyte Colony-Stimulating Factor
Humans
Leukemia, Promyelocytic, Acute / genetics*
Male
Middle Aged
Oncogenes / physiology
Translocation, Genetic / genetics*

Substances

Colony-Stimulating Factors
Granulocyte Colony-Stimulating Factor
DNA Restriction Enzymes