NR4A2 genetic variation in sporadic Parkinson's disease: a genewide approach

Mov Disord. 2006 Nov;21(11):1960-3. doi: 10.1002/mds.21018.

Abstract

The NR4A2 gene, which may cause autosomal dominant Parkinson's disease (PD), has also been reported to be a susceptibility factor for sporadic PD. Here, we use a haplotype-tagging approach in 802 PD patients and 784 controls and demonstrate that common genetic variation, including NR4A2 haplotypes, does not influence the risk of PD in the Caucasian population.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Chi-Square Distribution
  • DNA-Binding Proteins / genetics*
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genetic Variation*
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Nuclear Receptor Subfamily 4, Group A, Member 2
  • Parkinson Disease / genetics*
  • Transcription Factors / genetics*

Substances

  • DNA-Binding Proteins
  • NR4A2 protein, human
  • Nuclear Receptor Subfamily 4, Group A, Member 2
  • Transcription Factors