Global sperm deoxyribonucleic acid methylation is unaffected in protamine-deficient infertile males

Vincent W Aoki; Benjamin R Emery; Douglas T Carrell

doi:10.1016/j.fertnstert.2006.04.023

Global sperm deoxyribonucleic acid methylation is unaffected in protamine-deficient infertile males

Fertil Steril. 2006 Nov;86(5):1541-3. doi: 10.1016/j.fertnstert.2006.04.023. Epub 2006 Sep 29.

Authors

Vincent W Aoki¹, Benjamin R Emery, Douglas T Carrell

Affiliation

¹ Andrology and IVF Laboratories, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA.

PMID: 17011559
DOI: 10.1016/j.fertnstert.2006.04.023

Abstract

Sperm protamine-1 (P1) and protamine-2 (P2) concentrations were evaluated concomitantly with global DNA methylation patterns in a population of male infertility patients. Protamine quantification and immunofluorescence microscopy in conjunction with quantitative image analysis revealed no significant relationships between the P1/P2 ratio, P1 concentrations, or P2 concentrations and levels of global DNA methylation in mature spermatozoa.

Publication types

Controlled Clinical Trial

MeSH terms

Adult
DNA Methylation*
Humans
Infertility, Male / blood*
Infertility, Male / genetics*
Infertility, Male / pathology
Male
Protamines / blood*
Spermatogenesis / genetics*
Spermatozoa / metabolism*
Spermatozoa / pathology

Substances

PRM1 protein, human
Protamines
protamine 2