Abstract
Malaria-specific rapid diagnostic tests (RDTs) targeting aldolase show highly variable sensitivities. We assessed diversity in Plasmodium falciparum and P. vivax aldolases by sequencing the coding genes from parasites of various origins. The results show that aldolases are highly conserved, indicating that antigenic diversity is not a cause of variable RDT sensitivity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehyde-Lyases / genetics*
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Animals
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Conserved Sequence / genetics*
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DNA, Protozoan / chemistry
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DNA, Protozoan / genetics
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Genetic Variation*
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Humans
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Malaria / diagnosis*
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Malaria / parasitology
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Malaria, Falciparum / diagnosis
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Malaria, Falciparum / parasitology
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Malaria, Vivax / diagnosis
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Malaria, Vivax / parasitology
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Molecular Diagnostic Techniques
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Molecular Sequence Data
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Plasmodium falciparum / enzymology
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Plasmodium falciparum / genetics*
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Plasmodium falciparum / isolation & purification*
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Plasmodium vivax / enzymology
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Plasmodium vivax / genetics*
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Plasmodium vivax / isolation & purification*
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Protozoan Proteins / genetics
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Sequence Analysis, DNA
Substances
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DNA, Protozoan
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Protozoan Proteins
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Aldehyde-Lyases
Associated data
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GENBANK/DQ874471
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GENBANK/DQ874472
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GENBANK/DQ874473