Abstract
We were seeking for a mutual link between the -174G>C IL6 promoter polymorphism, history of the past acute respiratory infections and the long-term post-coronary artery bypass grafting (CABG) major adverse cardiovascular events (MACE) incidence. Two hundred thirty seven post-CABG patients have been followed up for a median period of 36 months. We found that past acute infections, influenza-like illness and lack of vaccination against influenza confer a significant risk of the post-CABG MACE incidence in the -174G allele carrying patients.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Aged
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Cohort Studies
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Comorbidity
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Coronary Artery Bypass / adverse effects
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Coronary Artery Bypass / statistics & numerical data*
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Coronary Disease / genetics*
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Coronary Disease / mortality
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Coronary Disease / surgery*
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Female
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Gene Expression Regulation
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Humans
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Influenza, Human / epidemiology
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Interleukin-6 / genetics*
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Male
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Middle Aged
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Polymorphism, Genetic*
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Postoperative Complications / epidemiology*
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Prognosis
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Respiratory Tract Infections / epidemiology
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Risk Assessment
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Treatment Outcome