Abstract
The +1480 C -->G mutation in the 3' untranslated region (UTR) of the human beta-globin gene has been associated with beta-thalassemia. A previously vali- dated in vitroexpression model used to assess the transcriptional impact of this 3'UTR mutation demonstrated that it has no effect on beta-globin gene expression.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
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Validation Study
MeSH terms
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Cell Line
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Cytosine*
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Globins / biosynthesis
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Globins / genetics*
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Guanine*
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Humans
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Mutation*
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Transcription, Genetic*
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Untranslated Regions / biosynthesis
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Untranslated Regions / genetics*
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beta-Thalassemia / genetics
Substances
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Untranslated Regions
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Guanine
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Cytosine
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Globins