Abstract
The PRDM1 gene, a master regulator of plasma cells (PC), can generate two transcription factor isoforms: PRDI-BF1alpha and PRDI-BF1beta. The present study shows that purified human normal PC have a significantly lower levels of PRDI-BF1beta expression than that in tumoral PC isolated from multiple myeloma (MM) (0.06+/-0.01 and 0.25+/-0.05, respectively; p<0.001). The role of this finding in MM is discussed.
Publication types
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Comparative Study
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Gene Expression Regulation, Neoplastic / genetics
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Gene Expression Regulation, Neoplastic / physiology*
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Humans
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Multiple Myeloma / genetics
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Multiple Myeloma / metabolism*
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Plasma Cells / metabolism*
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Positive Regulatory Domain I-Binding Factor 1
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Protein Isoforms / biosynthesis
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Protein Isoforms / genetics
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Repressor Proteins / biosynthesis*
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Repressor Proteins / genetics
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Transcription Factors / biosynthesis*
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Transcription Factors / genetics
Substances
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Protein Isoforms
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Repressor Proteins
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Transcription Factors
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PRDM1 protein, human
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Positive Regulatory Domain I-Binding Factor 1