Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese

Ann Hum Genet. 2006 Nov;70(Pt 6):778-83. doi: 10.1111/j.1469-1809.2006.00278.x.

Abstract

To investigate the association between polymorphisms in the G protein-coupled receptor kinase 4 gene (GRK4) (R65L, A142V and A486V) and essential hypertension in northern Han Chinese, we conducted a case-control study consisting of 503 individuals with essential hypertension (HT) and 490 age-, gender-, and area-matched normotensive (NT) controls. The three GRK4 variants were genotyped by PCR-RFLP analysis. Both haplotype and single locus analysis were used to process the genotyping data. The A486 allele showed a significant association with HT (P < 0.001). A total of 6 haplotypes were observed in the entire population, with the haplotypes L-V-A and R-A-A being found to be significantly related to hypertension (P= 0.001).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alleles
  • Case-Control Studies
  • China / epidemiology
  • Female
  • G-Protein-Coupled Receptor Kinase 4
  • Genetic Variation*
  • Haplotypes
  • Humans
  • Hypertension / epidemiology
  • Hypertension / genetics*
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Protein Serine-Threonine Kinases / genetics*

Substances

  • Protein Serine-Threonine Kinases
  • G-Protein-Coupled Receptor Kinase 4
  • GRK4 protein, human