Abstract
Defining the characteristics of leukemia stem cells is critical in order to better understand both the genesis of leukemic disease and strategies by which such cells may be eradicated. In this issue of Cancer Cell, Somervaille and Cleary describe studies in which the properties of malignant stem cells are elucidated in a mouse model of leukemia induced by expression of the MLL-AF9 translocation. Biological features of leukemia stem cells in this system challenge previous thinking in several ways and suggest an unexpected degree of heterogeneity among stem cells in various forms of leukemia.
Publication types
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Comment
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Comparative Study
MeSH terms
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Animals
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Bone Marrow Cells / cytology
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Cell Line, Transformed
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Cell Transformation, Neoplastic
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Coculture Techniques
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Disease Models, Animal
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Hematopoietic Stem Cell Transplantation
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Hematopoietic Stem Cells / metabolism
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Hematopoietic Stem Cells / pathology*
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Humans
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Leukemia, Experimental / etiology
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Leukemia, Experimental / genetics
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Leukemia, Experimental / pathology*
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Leukemia, Myeloid, Acute / blood
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Leukemia, Myeloid, Acute / genetics*
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Leukemia, Myeloid, Acute / pathology
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Mice
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Mice, Inbred C57BL
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Mice, Inbred Strains
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Mice, Transgenic
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Myeloid Cells / pathology*
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Oncogene Proteins, Fusion / genetics
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Oncogene Proteins, Fusion / metabolism*
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Proto-Oncogene Proteins c-kit / metabolism
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Retroviridae / genetics
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Spleen / pathology
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Transduction, Genetic
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Transplantation, Homologous
Substances
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Oncogene Proteins, Fusion
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Proto-Oncogene Proteins c-kit