Abstract
The association between the -76G>C in the 5'-flanking region and 723T>G in JWA exon three variants were examined for risk of leukemia development in a hospital-based case-control study of 201 leukemia patients and 243 cancer-free controls in a Chinese population. Studies showed that the -76C allele was associated with significantly increased odds of leukemia but the 723G allele was correlated with marked decreased odds of leukemia. Variation in the -76C allele resulted in almost complete loss of oxidative stress stimulated transcription activities of the promoter fragment.
Publication types
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Clinical Trial
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Multicenter Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Female
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Genetic Predisposition to Disease*
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Heat-Shock Proteins / genetics*
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Humans
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Intracellular Signaling Peptides and Proteins / genetics*
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Leukemia / genetics*
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Male
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Membrane Transport Proteins
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Middle Aged
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Oxidative Stress / genetics*
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Polymorphism, Single Nucleotide*
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Promoter Regions, Genetic*
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Retrospective Studies
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Transcription, Genetic
Substances
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ARL6IP5 protein, human
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Heat-Shock Proteins
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Intracellular Signaling Peptides and Proteins
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Membrane Transport Proteins