RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture

Eur J Endocrinol. 2006 Nov;155(5):645-53. doi: 10.1530/eje.1.02289.

Abstract

Papillary thyroid carcinoma (PTC) is frequently associated with RET gene rearrangements that generate the so-called RET/PTC oncogenes. In this review, we examine the data about the mechanisms of thyroid cell transformation, activation of downstream signal transduction pathways and modulation of gene expression induced by RET/PTC. These findings have advanced our understanding of the processes underlying PTC formation and provide the basis for novel therapeutic approaches to this disease.

Publication types

  • Lecture

MeSH terms

  • Animals
  • Carcinoma, Papillary / genetics*
  • Chromosomes, Human, Pair 10
  • Gene Expression Regulation, Neoplastic
  • Gene Rearrangement / genetics*
  • Humans
  • MAP Kinase Signaling System / physiology
  • Oncogene Proteins, Fusion / genetics
  • Protein-Tyrosine Kinases / genetics
  • Proto-Oncogene Proteins c-ret / genetics*
  • Thyroid Neoplasms / genetics*
  • Transcriptional Activation

Substances

  • Oncogene Proteins, Fusion
  • Protein-Tyrosine Kinases
  • Proto-Oncogene Proteins c-ret
  • RET protein, human
  • ret-PTC fusion oncoproteins, human