Cloning and sequencing of human FSH receptor cDNA

Biochem Biophys Res Commun. 1991 Mar 29;175(3):1125-30. doi: 10.1016/0006-291x(91)91682-3.

Abstract

We have isolated and sequenced a cDNA encoding the follicle stimulating hormone (FSH) receptor. The deduced amino acid sequence (678 residues) containing seven putative transmembrane segments which displays sequence similarity to G protein-coupled receptors. The receptor consists of 359 residue extracellular domain which contains four N-linked glycosylation sites. While the protein is 89% identical overall with the previously cloned rat FSH receptor, the most highly conserved regions are the putative transmembrane segments (95% similarity).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular / methods
  • DNA / genetics*
  • DNA / isolation & purification
  • Female
  • Gene Library
  • Glycosylation
  • Humans
  • Molecular Sequence Data
  • Ovary / physiology
  • Poly A / genetics
  • Poly A / isolation & purification
  • Protein Conformation
  • RNA / genetics
  • RNA / isolation & purification
  • RNA, Messenger
  • Rats
  • Receptors, FSH / genetics*
  • Receptors, LH / genetics
  • Restriction Mapping
  • Sequence Homology, Nucleic Acid

Substances

  • RNA, Messenger
  • Receptors, FSH
  • Receptors, LH
  • Poly A
  • RNA
  • DNA

Associated data

  • GENBANK/M62475
  • GENBANK/M62476
  • GENBANK/M62477
  • GENBANK/M62478
  • GENBANK/M62479
  • GENBANK/M62480
  • GENBANK/M62481
  • GENBANK/M62482
  • GENBANK/M63428
  • GENBANK/M65085