Human tyk2 kinase deficiency: another primary immunodeficiency syndrome

Wendy T Watford; John J O'Shea

doi:10.1016/j.immuni.2006.10.007

Human tyk2 kinase deficiency: another primary immunodeficiency syndrome

Immunity. 2006 Nov;25(5):695-7. doi: 10.1016/j.immuni.2006.10.007.

Authors

Wendy T Watford¹, John J O'Shea

Affiliation

¹ Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, MD 20892, USA.

PMID: 17098200
DOI: 10.1016/j.immuni.2006.10.007

Abstract

Janus kinases are critical for cytokine signaling. Mutations of Jak3 cause primary immunodeficiency, but Minegishi et al. (2006) now show that mutation of another Jak, tyrosine kinase 2, underlies another human immunodeficiency syndrome.

Publication types

Review

MeSH terms

Animals
Humans
Immunologic Deficiency Syndromes / genetics*
Immunologic Deficiency Syndromes / immunology
Immunologic Deficiency Syndromes / physiopathology
Mice
Mutation
TYK2 Kinase / deficiency*
TYK2 Kinase / genetics
TYK2 Kinase / immunology*

Substances

TYK2 Kinase
TYK2 protein, human