MHC class II genes in Mexican patients with idiopathic dilated cardiomyopathy

José Manuel Rodríguez-Pérez; José Manuel Fragoso; Edith Alvarez-León; Nancy Martínez-Rodríguez; Guillermo J Gallardo; Selene Inés-Real; Julio Granados; Pedro A Reyes; Gilberto Vargas-Alarcón

doi:10.1016/j.yexmp.2006.10.002

MHC class II genes in Mexican patients with idiopathic dilated cardiomyopathy

Exp Mol Pathol. 2007 Feb;82(1):49-52. doi: 10.1016/j.yexmp.2006.10.002. Epub 2006 Nov 28.

Authors

José Manuel Rodríguez-Pérez¹, José Manuel Fragoso, Edith Alvarez-León, Nancy Martínez-Rodríguez, Guillermo J Gallardo, Selene Inés-Real, Julio Granados, Pedro A Reyes, Gilberto Vargas-Alarcón

Affiliation

¹ Department of Physiology, Cardiovascular Disease's Genomic and Proteomic Study Group, Instituto Nacional de Cardiología Ignacio Chávez, Tlalpan 14080, Mexico City, Mexico.

PMID: 17126830
DOI: 10.1016/j.yexmp.2006.10.002

Abstract

The purpose of the present study was to evaluate the relationship between class II major histocompatibility complex (MHC) genes (HLA-DR and HLA-DQB) and the genetic susceptibility to idiopathic dilated cardiomyopathy (IDC) in Mexican patients. The HLA-DR and DQB alleles were analyzed in 53 patients with IDC and 99 ethnically matched healthy controls using the polymerase chain reaction-sequence specific oligonucleotides (PCR-SSO) technique. IDC patients showed increased frequencies of HLA-DR4 (pC=0.02, OR=1.87), HLA-DQB1*0301 (pC=0.02, OR=1.92) and HLA-DQB1*0302 (pC=0.02, OR=1.87) when compared to healthy controls. On the other hand, IDC patients also showed decreased frequencies of HLA-DR11 allele (pC=0.03, OR=0.26) and HLA-DQB1*0201 (pC=0.04, OR=0.41). These data suggest that variation in class II HLA alleles could be a genetic factor involved in the susceptibility to IDC of the Mexican Mestizo population.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cardiomyopathy, Dilated / genetics*
Genes, MHC Class II*
Genetic Predisposition to Disease*
Humans
Mexico
Polymerase Chain Reaction