Abstract
15-Lipoxygenase 2 (15-LOX2) is the major mammalian lipoxygenase expressed in normal human adult prostate and its expression is decreased or lost in high-grade prostate intraepithelial neoplasia (HGPIN) and prostate cancer (PCa). Our recent work has demonstrated that (1) 15-LOX2 has multiple alternatively spliced isoforms and is a negative cell-cycle regulator in normal human prostate (NHP) epithelial cells; (2) 15-LOX2 in NHP cells is positively regulated by Sp1 and negatively regulated by Sp3; (3) 15-LOX2 in NHP cells may be partially involved in cell differentiation; (4) 15-LOX2 is cell-autonomously upregulated in cultured NHP cells and its induction is associated with NHP cell senescence; and (5) 15-LOX2 is a functional prostate tumor suppressor. Here we summarize these new findings to provide a concise view of the potential biological functions of 15-LOX2 in NHP cells and of its deregulation in PCa development.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Review
MeSH terms
-
Adult
-
Alternative Splicing
-
Arachidonate 15-Lipoxygenase / genetics
-
Arachidonate 15-Lipoxygenase / physiology*
-
Cadherins / physiology
-
Cell Cycle Proteins / physiology*
-
Cell Differentiation
-
Cell Enlargement
-
Cellular Senescence
-
Epithelial Cells / cytology*
-
Gene Expression
-
Humans
-
Hydroxyeicosatetraenoic Acids / physiology
-
Male
-
Prostate / cytology*
-
Prostatic Neoplasms / physiopathology
-
Receptors, Androgen / physiology
-
Sp1 Transcription Factor / physiology
-
Sp3 Transcription Factor / physiology
-
Tumor Suppressor Proteins / physiology*
Substances
-
Cadherins
-
Cell Cycle Proteins
-
Hydroxyeicosatetraenoic Acids
-
Receptors, Androgen
-
SP3 protein, human
-
Sp1 Transcription Factor
-
Tumor Suppressor Proteins
-
Sp3 Transcription Factor
-
15-hydroxy-5,8,11,13-eicosatetraenoic acid
-
ALOX15B protein, human
-
Arachidonate 15-Lipoxygenase