[Expression of BDNF and trk B in the cochleas of the aged rats]

Yuru Li; Delong Liu; Yuanyuan Zhang; Ping Wang; Baodong Du

[Expression of BDNF and trk B in the cochleas of the aged rats]

Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 Oct;20(19):894-5.

[Article in Chinese]

Authors

Yuru Li¹, Delong Liu, Yuanyuan Zhang, Ping Wang, Baodong Du

Affiliation

¹ Department of Otolaryngology, First Hospital of Harbin Medical University, Harbin 150001, China.

PMID: 17168119

Abstract

Objective: To explore the correlation between the expression of brain derived neurotrophic factor (BDNF) and presbycusis in the cochleae of the aged rats.

Method: The mRNA expression of BDNF and presbycusis in the cochleas of the aged rats was quantitated by real time PCR.

Result: The expression of BDNF in the cochleas of the aged rats with presbycusis was obviously less than that in the control group. And the difference was statistically significant.

Conclusion: The expression of BDNF is closely correlated to presbycusis in the aged rats.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Aging*
Animals
Brain-Derived Neurotrophic Factor / metabolism*
Cochlea / metabolism*
Rats
Rats, Wistar
Receptor, trkB / metabolism*

Substances

Brain-Derived Neurotrophic Factor
Receptor, trkB