Investigation of KIR gene frequencies in type 1 diabetes mellitus

Derek Middleton; Iris Halfpenny; Ashley Meenagh; Fionnula Williams; Jyrki Sivula; Eva Tuomilehto-Wolf

doi:10.1016/j.humimm.2006.08.295

Investigation of KIR gene frequencies in type 1 diabetes mellitus

Hum Immunol. 2006 Dec;67(12):986-90. doi: 10.1016/j.humimm.2006.08.295. Epub 2006 Oct 2.

Authors

Derek Middleton¹, Iris Halfpenny, Ashley Meenagh, Fionnula Williams, Jyrki Sivula, Eva Tuomilehto-Wolf

Affiliation

¹ Northern Ireland Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, and University of Ulster, Coleraine, Northern Ireland. derek.middleton@bll.n-i.nhs.uk

PMID: 17174747
DOI: 10.1016/j.humimm.2006.08.295

Abstract

The frequency of killer immunoglobulinlike receptors (KIR) genes was examined in type 1 diabetes mellitus patients and controls from Finland. The KIR gene 2DS5 was significantly decreased in patients versus controls, but this was no longer significant after correction for the number of comparisons made.

Publication types

Comparative Study

MeSH terms

Adolescent
Adult
Aged
Child
Child, Preschool
Diabetes Mellitus, Type 1 / genetics*
Diabetes Mellitus, Type 1 / immunology
Female
Finland
Gene Frequency* / immunology
Humans
Male
Middle Aged
Monomeric GTP-Binding Proteins / genetics*
Monomeric GTP-Binding Proteins / immunology
Mutation, Missense* / immunology

Substances

GEM protein, human
Monomeric GTP-Binding Proteins