Background: Tumor protein p53-induced nuclear protein 1 (TP53INP1) is a stress-induced protein and plays a role in cell cycle arrest and p53-mediated apoptosis. In this study, TP53INP1 expression in human breast carcinoma was investigated.
Materials and methods: TP53INP1 and aberrant p53 expression were investigated immunohistochemically in 81 cases of breast carcinoma.
Results: Diffuse and intense TP53INP1 expression was observed in the normal mammary gland. Decreased TP53INP1 expression was found in 45 cases (55.6%) of breast carcinoma. The TP53INP1 expression level was inversely linked to tumor size, positive lymph node metastasis, high histological grade and aberrant p53 expression.
Conclusion: Decreased expression of TP53INP1 is involved in breast carcinoma progression.