BDNF genotype potentially modifying the association between incident stroke and depression

Neurobiol Aging. 2008 May;29(5):789-92. doi: 10.1016/j.neurobiolaging.2006.11.021. Epub 2007 Jan 11.

Abstract

Objective: To investigate the role of the brain-derived neurotrophic factor (BDNF) gene val66met polymorphism in the association between stroke and depression.

Method: Five hundred community residents aged >65 years without stroke or depression at baseline were re-evaluated after 2 years. Disability (World Health Organization Disability Assessment Schedule, WHODAS II), cognitive function (Mini-Mental State Examination, MMSE), and BDNF genotype were also measured at baseline.

Results: The association between incident stroke and depression was strengthened progressively with increasing numbers of met alleles, and was only significant in subjects with the met/met genotype after adjustment for disability and cognitive function.

Conclusion: The BDNF val66met polymorphism may modify the association between stroke and depression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Brain-Derived Neurotrophic Factor / genetics*
  • Comorbidity
  • Depression / diagnosis
  • Depression / epidemiology*
  • Depression / genetics*
  • Female
  • Genetic Predisposition to Disease / epidemiology
  • Genetic Predisposition to Disease / genetics
  • Genotype
  • Humans
  • Incidence
  • Korea / epidemiology
  • Male
  • Polymorphism, Single Nucleotide / genetics
  • Risk Assessment / methods*
  • Risk Factors
  • Stroke / diagnosis
  • Stroke / epidemiology*
  • Stroke / genetics*

Substances

  • Brain-Derived Neurotrophic Factor