Purpose of review: Whereas much investigation in atopic dermatitis has focused upon the adaptive immune response, new data suggest that allergic sensitization may occur secondary to impairment of skin barrier function.
Recent findings: Two common loss-of-function mutations in the FLG gene encoding filaggrin (an important component of terminal keratinocyte differentiation) are strongly associated with the development of atopic dermatitis and asthma associated with atopic dermatitis.
Summary: Genetic defects in skin barrier function should be recognized as major risk factors for the development of atopic dermatitis and asthma.