Interleukin-6 gene amplification and shortened survival in glioblastoma patients

A Tchirkov; T Khalil; E Chautard; K Mokhtari; L Véronèse; B Irthum; P Vago; J-L Kémény; P Verrelle

doi:10.1038/sj.bjc.6603586

Interleukin-6 gene amplification and shortened survival in glioblastoma patients

Br J Cancer. 2007 Feb 12;96(3):474-6. doi: 10.1038/sj.bjc.6603586. Epub 2007 Jan 16.

Authors

A Tchirkov¹, T Khalil, E Chautard, K Mokhtari, L Véronèse, B Irthum, P Vago, J-L Kémény, P Verrelle

Affiliation

¹ EA 3846, Université d'Auvergne, Clermont-Ferrand, F-63001, France. andrei.tchirkov@cjp.fr

Abstract

Interleukin-6 (IL-6) is known to promote tumour growth and survival. We evaluated IL-6 gene amplification in tumours from 53 glioma patients using fluorescence in situ hybridisation. Amplification events were detected only in glioblastomas (15 out of 36 cases), the most malignant tumours, and were significantly associated with decreased patient survival.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Gene Amplification*
Glioblastoma / genetics*
Glioblastoma / mortality
Humans
In Situ Hybridization, Fluorescence
Interleukin-6 / genetics*

Substances

Interleukin-6