Abstract
In a recent issue of Molecular Cell, Sicinski and colleagues report the surprising discovery that cyclin E promotes replication licensing and transformation independently of CDKs, resolving inconsistencies of inactivating cyclin E and CDK2 in the mouse and cells.
MeSH terms
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Animals
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Cyclin E / deficiency
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Cyclin E / genetics
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Cyclin E / metabolism*
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Cyclin-Dependent Kinase 2 / deficiency
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Cyclin-Dependent Kinase 2 / genetics
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Cyclin-Dependent Kinase 2 / metabolism
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DNA Replication*
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Mice
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Mice, Knockout
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Models, Biological
Substances
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Cyclin E
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Cdk2 protein, mouse
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Cyclin-Dependent Kinase 2