Life without kinase: cyclin E promotes DNA replication licensing and beyond

Mol Cell. 2007 Jan 26;25(2):175-6. doi: 10.1016/j.molcel.2007.01.008.

Abstract

In a recent issue of Molecular Cell, Sicinski and colleagues report the surprising discovery that cyclin E promotes replication licensing and transformation independently of CDKs, resolving inconsistencies of inactivating cyclin E and CDK2 in the mouse and cells.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Cyclin E / deficiency
  • Cyclin E / genetics
  • Cyclin E / metabolism*
  • Cyclin-Dependent Kinase 2 / deficiency
  • Cyclin-Dependent Kinase 2 / genetics
  • Cyclin-Dependent Kinase 2 / metabolism
  • DNA Replication*
  • Mice
  • Mice, Knockout
  • Models, Biological

Substances

  • Cyclin E
  • Cdk2 protein, mouse
  • Cyclin-Dependent Kinase 2