JAK3 mutations occur in acute megakaryoblastic leukemia both in Down syndrome children and non-Down syndrome adults

Leukemia. 2007 Mar;21(3):574-6. doi: 10.1038/sj.leu.2404527. Epub 2007 Jan 25.
No abstract available

Publication types

  • Comparative Study
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Binding Sites / genetics
  • Child
  • DNA Mutational Analysis
  • DNA, Neoplasm / genetics
  • Disease Progression
  • Down Syndrome / complications*
  • Enzyme Activation / genetics
  • Female
  • GATA1 Transcription Factor / genetics
  • Genes, ras
  • Genetic Predisposition to Disease
  • Humans
  • Interleukin Receptor Common gamma Subunit / metabolism
  • Janus Kinase 3 / genetics*
  • Leukemia, Megakaryoblastic, Acute / complications
  • Leukemia, Megakaryoblastic, Acute / enzymology
  • Leukemia, Megakaryoblastic, Acute / genetics*
  • Male
  • Myeloproliferative Disorders / complications
  • Myeloproliferative Disorders / enzymology
  • Myeloproliferative Disorders / genetics*
  • Neoplasm Proteins / genetics*
  • Protein Structure, Tertiary
  • Structure-Activity Relationship
  • Tumor Suppressor Protein p53 / genetics
  • fms-Like Tyrosine Kinase 3 / genetics

Substances

  • DNA, Neoplasm
  • GATA1 Transcription Factor
  • GATA1 protein, human
  • Interleukin Receptor Common gamma Subunit
  • Neoplasm Proteins
  • Tumor Suppressor Protein p53
  • FLT3 protein, human
  • fms-Like Tyrosine Kinase 3
  • JAK3 protein, human
  • Janus Kinase 3