Molecular pathogenesis of osteosarcoma

DNA Cell Biol. 2007 Jan;26(1):1-18. doi: 10.1089/dna.2006.0505.

Abstract

Osteosarcoma is a devastating but rare disease, whose study has illuminated both the basic biology and clinical management of cancer over the past 30 years. These contributions have included insight into the roles of key cancer genes such as the retinoblastoma tumor suppressor gene and TP53, the identification of familial cancer syndromes implicating DNA helicases, and dramatic improvements in survival by the use of adjuvant chemotherapy. This review provides a synoptic overview of our current understanding of the molecular causes of osteosarcoma, and suggests future directions for study.

Publication types

  • Review

MeSH terms

  • Animals
  • Bloom Syndrome / genetics
  • Bloom Syndrome / pathology
  • Bone Neoplasms / genetics*
  • Bone Neoplasms / metabolism
  • Bone Neoplasms / pathology
  • Chromosome Aberrations
  • Cytoskeletal Proteins / genetics
  • Cytoskeletal Proteins / metabolism
  • Genetic Predisposition to Disease
  • Humans
  • Matrix Metalloproteinases / genetics
  • Matrix Metalloproteinases / metabolism
  • Mice
  • Mutation
  • Neoplasm Invasiveness
  • Neoplasm Metastasis
  • Neurofibromin 2 / genetics
  • Neurofibromin 2 / metabolism
  • Osteitis Deformans / genetics
  • Osteitis Deformans / pathology
  • Osteosarcoma / genetics*
  • Osteosarcoma / metabolism
  • Osteosarcoma / pathology
  • RecQ Helicases / genetics
  • RecQ Helicases / metabolism
  • Retinoblastoma Protein / genetics
  • Retinoblastoma Protein / metabolism
  • Rothmund-Thomson Syndrome / genetics
  • Rothmund-Thomson Syndrome / pathology
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism
  • Werner Syndrome / genetics
  • Werner Syndrome / pathology

Substances

  • Cytoskeletal Proteins
  • Neurofibromin 2
  • Retinoblastoma Protein
  • Tumor Suppressor Protein p53
  • ezrin
  • Matrix Metalloproteinases
  • RecQ Helicases