Aims: To investigate levels of free interleukin-2 (IL-2) receptors in relation to differing levels of CIPD in children with trisomy 21 (Down's syndrome).
Design: Cross-sectional study of soluble IL-2 receptors in serum samples.
Sample and method: Eighty children aged 10-13 years were included; 40 children with Down's syndrome and with varying levels of CIPD and 40 control children without Down's syndrome and without periodontitis. Serum samples were analysed using an enzyme-linked immunosorbent assay (ELISA) with two monoclonal antibodies.
Results: In children with Down's syndrome and periodontitis, serum IL-2 receptor levels were significantly higher than in control subjects.