Abstract
The t(8;16)(p11;p13) translocation, associated with poor prognosis acute monocytic leukemia, fuses MYST3 on chromosome region 8p11 to CBP on chromosome region 16p13. Two types of MYST3-CBP and CBP-MYST3 fusion transcripts have been identified in patients. We describe two new types of MYST3-CBP transcripts and a new primer set.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Carrier Proteins / genetics*
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Chromosomes, Human, Pair 16*
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Chromosomes, Human, Pair 8*
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Corticosterone
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DNA Primers / chemistry
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Female
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Histone Acetyltransferases / genetics*
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Humans
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Leukemia, Myeloid, Acute / genetics*
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Male
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Middle Aged
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Oncogene Proteins, Fusion / biosynthesis
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Oncogene Proteins, Fusion / genetics*
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Prognosis
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Reverse Transcriptase Polymerase Chain Reaction / methods*
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Translocation, Genetic*
Substances
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Carrier Proteins
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DNA Primers
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Oncogene Proteins, Fusion
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Histone Acetyltransferases
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KAT6A protein, human
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Corticosterone