The V617F mutation of JAK2 is very uncommon in patients with thrombosis

Haematologica. 2007 Feb;92(2):285-6. doi: 10.3324/haematol.10358.

Abstract

Given that many cases of thrombosis do not have a clear cause, a myeloproliferative disease could be involved. We investigated the V617F mutation of the JAK2 gene in 295 patients with thrombosis. Only one case was positive. Therefore, the study of this mutation is not necessary in all patients with idiopathic thrombosis.

Publication types

  • Letter

MeSH terms

  • Aged
  • Cohort Studies
  • Female
  • Hemoglobins / metabolism
  • Humans
  • Janus Kinase 2 / blood*
  • Janus Kinase 2 / genetics*
  • Male
  • Middle Aged
  • Mutation*
  • Polycythemia Vera / complications
  • Polycythemia Vera / genetics
  • Thrombocythemia, Essential / complications
  • Thrombocythemia, Essential / genetics
  • Thrombosis / blood*
  • Thrombosis / genetics*

Substances

  • Hemoglobins
  • Janus Kinase 2