The C19007T polymorphism of ERCC1 and its correlation with the risk of epithelial ovarian and endometrial cancer in Korean women. A case control study

Gynecol Obstet Invest. 2007;64(2):84-8. doi: 10.1159/000100008. Epub 2007 Feb 20.

Abstract

Background: Excision repair cross-complementing group 1 (ERCC1) is a major DNA repair protein. Recent studies have addressed the association between ERCC1 polymorphism and carcinogenesis.

Methods: We investigated a polymorphism of ERCC1 at nucleotide 19007 (C-->T, Asn118Asn) in 94 epithelial ovarian cancer patients, 102 endometrial cancer patients, and in 329 control subjects.

Results: We observed no evidence of associations between the C19007T ERCC1 polymorphism and risk of epithelial ovarian or endometrial cancer, which had the same adjusted odds ratios of 0.91 (p = 0.711, 0.691 respectively).

Conclusion: Our findings suggest that the C19007T ERCC1 polymorphism is unlikely to play an important role in epithelial ovarian or endometrial cancer in Korean women.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Case-Control Studies
  • Chi-Square Distribution
  • DNA-Binding Proteins / genetics*
  • Endometrial Neoplasms / epidemiology
  • Endometrial Neoplasms / genetics*
  • Endometrial Neoplasms / pathology
  • Endonucleases / genetics*
  • Female
  • Genotype
  • Humans
  • Korea / epidemiology
  • Logistic Models
  • Middle Aged
  • Neoplasms, Glandular and Epithelial / epidemiology
  • Neoplasms, Glandular and Epithelial / genetics*
  • Neoplasms, Glandular and Epithelial / pathology
  • Odds Ratio
  • Ovarian Neoplasms / epidemiology
  • Ovarian Neoplasms / genetics*
  • Ovarian Neoplasms / pathology
  • Polymorphism, Genetic*
  • Prospective Studies
  • Risk Factors

Substances

  • DNA-Binding Proteins
  • ERCC1 protein, human
  • Endonucleases