The genetic susceptibility to IgA nephropathy: a novel functional candidate gene for incomplete O-glycosylation of IgA1

Kidney Int. 2007 Mar;71(5):379-81. doi: 10.1038/sj.ki.5002139.

Abstract

Incompleteness of O-glycosylation in the IgA1 hinge has been implicated as a central mechanism in the development of IgA nephropathy. Although underglycosylation was reported to be an acquired abnormality, genes for enzymes of O-glycosylation, such as C1GALT1, may be responsible for susceptibility to IgA nephropathy.

Publication types

  • Comment

MeSH terms

  • Galactosyltransferases / genetics*
  • Genetic Predisposition to Disease*
  • Glomerulonephritis, IGA / enzymology
  • Glomerulonephritis, IGA / genetics*
  • Glycosylation
  • Humans
  • Immunoglobulin A / metabolism*

Substances

  • Immunoglobulin A
  • C1GALT1 protein, human
  • Galactosyltransferases