Abstract
TGFbeta functions as a tumor suppressor in some contexts and a tumor promoter in others. In a recent issue of Cancer Cell, Bruna et al. (2007) shed light on an epigenetic mechanism that underlies this schizophrenic behavior in malignant glioma. Their findings highlight a stem cell/cancer link...and a potential blind spot in large-scale cancer genome sequencing projects.
MeSH terms
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Animals
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Brain Neoplasms / genetics*
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Brain Neoplasms / metabolism
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Brain Neoplasms / physiopathology
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Cell Transformation, Neoplastic / genetics
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Cell Transformation, Neoplastic / metabolism
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DNA Methylation*
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Epigenesis, Genetic / genetics
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Gene Expression Regulation, Neoplastic / genetics*
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Glioma / genetics*
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Glioma / metabolism
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Glioma / physiopathology
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Humans
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Smad Proteins / genetics*
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Smad Proteins / metabolism
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Stem Cells / metabolism
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Transforming Growth Factor beta / genetics*
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Transforming Growth Factor beta / metabolism
Substances
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Smad Proteins
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Transforming Growth Factor beta