Abstract
There is growing interest in the potential use of 5-HT(1A) receptor agonists as neuroprotective agents in stroke and traumatic brain injury. However, a new study using a recombinant 5-HT(1A) receptor cell line suggests that these agonists may promote as well as inhibit apoptotic responses. Because heterologously expressed receptors may couple promiscuously to inappropriate signal transduction pathways, the results should be interpreted with caution.
MeSH terms
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Animals
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Apoptosis / drug effects*
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Brain Injuries / drug therapy
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Brain Injuries / enzymology*
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Gene Expression
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Humans
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MAP Kinase Kinase 4 / metabolism*
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Neuroprotective Agents / pharmacology*
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Neuroprotective Agents / therapeutic use
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Receptor, Serotonin, 5-HT1A* / genetics
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Receptor, Serotonin, 5-HT1A* / therapeutic use
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Recombinant Proteins / genetics
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Recombinant Proteins / pharmacology
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Recombinant Proteins / therapeutic use
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Serotonin Receptor Agonists / metabolism
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Signal Transduction / drug effects
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Stroke / drug therapy
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Stroke / enzymology*
Substances
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Neuroprotective Agents
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Recombinant Proteins
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Serotonin Receptor Agonists
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Receptor, Serotonin, 5-HT1A
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MAP Kinase Kinase 4