A new hypothesis on the role of c-erbB2 oncogene in the progress of breast cancer
Bull Exp Biol Med. 2006 Jul;142(1):94-7.
doi: 10.1007/s10517-006-0301-2.
[Article in
English,
Russian]
Affiliation
- 1 Clinical Oncological Center, Ministry of Health of Republic of Tatarstan, Kazan. semyonp@mail.ru
Abstract
Proliferation and the state of adhesion molecules (E-cadherin, galectin-3) and estrogen and progesterone receptors were immunohistochemically analyzed in breast cancer biopsy specimens under conditions of c-erbB2 overexpression with and without gene amplification. It was hypothesized that c-erbB2 overexpression without gene amplification led to suppression of proliferation and "conservation" of tumor cell.
MeSH terms
-
Biopsy
-
Breast Neoplasms / genetics*
-
Breast Neoplasms / metabolism*
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Cadherins / metabolism
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Cyclin-Dependent Kinase Inhibitor p21 / metabolism
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Disease Progression
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Female
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Galectin 3 / metabolism
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Gene Expression Regulation, Neoplastic*
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Humans
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Immunohistochemistry
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In Situ Hybridization, Fluorescence
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Receptor, ErbB-2 / genetics
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Receptor, ErbB-2 / metabolism*
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Receptors, Estrogen / metabolism
-
Receptors, Progesterone / metabolism
Substances
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Cadherins
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Cyclin-Dependent Kinase Inhibitor p21
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Galectin 3
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Receptors, Estrogen
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Receptors, Progesterone
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Receptor, ErbB-2