A new hypothesis on the role of c-erbB2 oncogene in the progress of breast cancer

Bull Exp Biol Med. 2006 Jul;142(1):94-7. doi: 10.1007/s10517-006-0301-2.
[Article in English, Russian]

Abstract

Proliferation and the state of adhesion molecules (E-cadherin, galectin-3) and estrogen and progesterone receptors were immunohistochemically analyzed in breast cancer biopsy specimens under conditions of c-erbB2 overexpression with and without gene amplification. It was hypothesized that c-erbB2 overexpression without gene amplification led to suppression of proliferation and "conservation" of tumor cell.

Publication types

  • Comparative Study

MeSH terms

  • Biopsy
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / metabolism*
  • Cadherins / metabolism
  • Cyclin-Dependent Kinase Inhibitor p21 / metabolism
  • Disease Progression
  • Female
  • Galectin 3 / metabolism
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization, Fluorescence
  • Receptor, ErbB-2 / genetics
  • Receptor, ErbB-2 / metabolism*
  • Receptors, Estrogen / metabolism
  • Receptors, Progesterone / metabolism

Substances

  • Cadherins
  • Cyclin-Dependent Kinase Inhibitor p21
  • Galectin 3
  • Receptors, Estrogen
  • Receptors, Progesterone
  • Receptor, ErbB-2