Melanotic neuroectodermal tumor of infancy: report of a case with myogenic differentiation

Pediatr Dev Pathol. 2007 Mar-Apr;10(2):157-60. doi: 10.2350/06-07-0138.1.

Abstract

An 8-month-old boy presented with a 6-week history of a skull mass of the anterior fontanelle. The mass was excised, and the histopathologic features were diagnostic for melanotic neuroectodermal tumor of infancy. The tumor showed focal myogenin positivity, which has not been previously reported in this tumor. The patient has no evidence of recurrent tumor 10 months after the excision. No adjuvant therapy was given. In addition, we stained a case of melanotic neuroectodermal tumor of infancy obtained from Columbus Children's Hospital; focal myogenin positivity was present.

Publication types

  • Case Reports

MeSH terms

  • Antigens, Neoplasm
  • Follow-Up Studies
  • Humans
  • Immunohistochemistry
  • Infant
  • Keratins / metabolism
  • Male
  • Melanoma-Specific Antigens
  • Myogenin / metabolism*
  • Neoplasm Proteins / metabolism
  • Neuroectodermal Tumor, Melanotic / diagnosis*
  • Neuroectodermal Tumor, Melanotic / diagnostic imaging
  • Neuroectodermal Tumor, Melanotic / metabolism
  • Neuroectodermal Tumor, Melanotic / pathology
  • Neuroectodermal Tumor, Melanotic / surgery
  • Phosphopyruvate Hydratase / metabolism
  • Radiography
  • Skull Neoplasms / diagnosis*
  • Skull Neoplasms / diagnostic imaging
  • Skull Neoplasms / metabolism
  • Skull Neoplasms / pathology
  • Skull Neoplasms / surgery
  • Time Factors
  • Treatment Outcome

Substances

  • Antigens, Neoplasm
  • Melanoma-Specific Antigens
  • Myogenin
  • Neoplasm Proteins
  • Keratins
  • Phosphopyruvate Hydratase